Plymouth Respiratory Research Partnership

Dr Matthew Masoli

Dr Matthew Masoli graduated from Charing Cross and Westminster Medical school in 1997. Post membership he obtained a research fellowship at the Medical Research Institute of New Zealand with Professor Richard Beasley, where he undertook research into the dose-response profile of inhaled corticosteroids both in terms of efficacy and adverse effects. This formed the basis of his MD thesis and provided numerous peer-reviewed publications. Following completion of that study, he returned to the UK to complete his specialist registrar training in respiratory medicine in the South West.

Dr Masoli was appointed a full-time NHS consultant in respiratory and general medicine at Derriford Hospital, Plymouth, in 2009. Dr Masoli has a particular interest in patients with severe asthma or asthma that is difficult to control and leads the asthma service at Plymouth Hospitals NHS Trust. His team specialises in the systematic evaluation of patients with difficult-to-control asthma, sent for a tertiary or second opinion from their local hospital. He is also actively involved in a number of clinical trials in severe asthma.

Major reports

Global Burden of Asthma Report 2004. www.ginasthma.com This report was commissioned by the Global Initiative for Asthma (GINA) to provide data on the global burden of asthma in 20 regions worldwide based on literature primarily published through the International Study of Asthma and Allergy in Childhood (ISSAC) and the European Community Respiratory Health Survey (ECRHS). The report provided data on the prevalence of clinical asthma, mortality rates from asthma and also case fatality rates. The report has been an important source of information for those wishing to explore available data on the burden of asthma by region and will be updated as new information becomes available.

Publications

Editorials
  1. What to do at step 3 of the asthma guidelines – increase the dose of inhaled corticosteroids or add a long acting β-agonist drug? Matthew Masoli, Shaun Holt, Richard Beasley. J Allergy Clin Immunol 2003; 112(1): 10-12
  2. Increasing compliance with inhaled corticosteroids through the use of combination therapy – M. Masoli, R Beasley. J allergy Clin Immunol 2004; Vol 13 No 2: 219-220.
  3. Optimal starting dose of inhaled corticosteroids in adult asthma: why has it taken so long? Masoli M, Weatherall M, Beasley R. Thorax 2005; 60(2): 93-4
  4. Metered dose inhalers: a need for dose counters. Holt S, Weatherall M, Masoli M, Beasley R. Respirology 2005; 10(1): 105-6
  5. Clinical importance of the step 3 choice in asthma. Barnes ML, Lipworth BJ, Weatherall M, Masoli M, Beasley R. Thorax 2006; 61(2): 180-1
Peer reviewed journals
  1. The use of isotonic nebulised Magnesium sulphate as an adjuvant to salbutamol in the treatment of severe asthma in adults. Rodney Hughes, Alexandra Goldkorn, Matthew Masoli, Mark Weatherall, Carl Burgess, Richard Beasley. Lancet 2003; 361: 2114-17.
  2. Dose-response relation of budesonide in adolescents and adults with asthma: meta-analysis. Matthew Masoli, Shaun Holt, Mark Weatherall, Rodney Hughes, Richard Beasley. Eur Resp J. 2004; 23(4): 552-8
  3. Dose-response relation of inhaled Fluticasone Propionate in children with asthma – a systematic review of its efficacy and adrenal effects. Matthew Masoli, Shaun Holt, Mark Weatherall, Richard Beasley. Archives of Diseases of Childhood 2004; 89(10): 902-7
  4. The clinical dose-response relationship of Fluticasone Propionate in adults with asthma. Matthew Masoli, Shaun Holt, Mark Weatherall, Richard Beasley. Thorax 2004; 59(1): 16-20
  5. Budesonide Once versus Twice daily administration: Meta-analysis. Matthew Masoli, Mark Weatherall, Richard Beasley. Respirology 2004; 9(4): 528-34
  6. The dose-response relationship of inhaled corticosteroids in asthma. Masoli M, Holt S, Weatherall M, Beasley R. Curr Allergy Asthma Rep. 2004;4(2):144–148.
  7. The 24h duration of bronchodilation of fluticasone/salmeterol combination administered in the evening. Matthew Masoli, Mark Weatherall, Richard Beasley. Respiratory Medicine 2005; 99(5): 545-52
  8. Fluticasone given once versus twice a day: meta-analysis. Masoli M, Weatherall M, Beasley R. Respirology 2005; 10(2): 183-8
  9. Fixed and adjustable dose asthma action plans based on combination therapy: a pilot study. Holt S, Ryder-Lewis S, Masoli M, Weatherall M, Beasley R. Respirology 2005; 10(4): 497-503
  10. Moderate dose inhaled corticosteroids plus salmeterol versus higher doses of inhaled corticosteroids in symptomatic asthma. Masoli M, Weatherall M, Holt S, Beasley R. Thorax 2005; 60(9): 730-4
  11. The 24h duration of bronchodilation of budesonide/formoterol combination administered in the evening. Matthew Masoli, Mark Weatherall, Richard Beasley. Respiratory Medicine 2006; 100(1): 20-5
  12. Inhaled fluticasone propionate and adrenal effects in adult asthma: systematic review and meta-analysis. M. Masoli, M. Weatherall, S. Holt, P. Shirtcliffe and R. Beasley. Eur Respir J 2006; 28:960-967
  13. Dose-response relationship for risk of non-vertebral fracture with inhaled corticosteroids. Weatherall M, James K, Clay J Perrin K, Masoli M, Wijesinghe M, Beasley R. Clin Exp Allergy 2008; Vol 38 issue 9: Pages 1451 - 1458
Review articles
  1. The use of adult asthma management protocols in the emergency department. Matthew Masoli, Rodney Hughes, Geoffrey Hughes, Richard Beasley. Asthma Journal; 2002:7 140-2
  2. Evidence that current therapeutic goals have not been met in asthma. Beasley R. Masoli M. Primary Care Respiratory Journal. Vol 11(SUPPL. 1) (pp S3-S6), 2002.
  3. Asthma assessment and management protocols in the emergency department. Matthew Masoli, Rodney Hughes, Geoffrey Hughes, Richard Beasley. New Zealand Medical Journal. 24 Jan 2003 Vol 116 No 1168
  4. Diagnosis and management of adult asthma. Matthew Masoli, Richard Beasley. Medicine Respiratory II Chapter 2003
  5. Asthma in New Zealand – Time to get control. Richard Beasley, Matthew Masoli. New Zealand Medical Journal 16 May 2003 Vol 116 No 1174
  6. The dose-response relationship of inhaled corticosteroids in asthma. Matthew Masoli, Shaun Holt, Mark Weatherall, Richard Beasley. Current Allergy and Asthma Reports 2004; 4(2): 144-148
  7. The use of the self-management plan system of care in adult asthma. Shaun Holt, Matthew Masoli, Richard Beasley. Primary Care Respiratory Journal 2004
  8. Global Burden of Asthma Report. Matthew Masoli, Denise Fabian, Shaun Holt, Richard Beasley. Global Initiative for Asthma 2004. www.ginasthma.com
  9. The Global Burden of Asthma: executive summary of the GINA Dissemination Committee report. Matthew Masoli, Denise Fabian, Shaun Holt, Richard Beasley. Allergy 2004; 59(5): 469-78
Book chapters
  1. Inhaled Corticosteroid Therapy in the Management of Asthma in Adults. Matthew Masoli, Richard Beasley. Book Chapter. Pharmacotherapy of Asthma by James T Li. Publisher(s): Taylor & Franci 2006
  2. Inhaled corticosteroid therapy in the management of asthma in adults. Masoli M, Holt S, Weatherall M, Shirtcliffe P, Beasley R. The Pharmacotherapy of Asthma. New York: Marcel Dekker 2005, 83-115
  3. Respiratory Muscle Function chapter. Oxford Desk Reference: Respiratory Medicine. Masoli M, Hughes P. Oxford University Press 2008.
Letters
  1. Nebulised salbutamol and magnesium sulphate in acute asthma. Authors' reply. Rodney Hughes, Alexandra Goldkorn, Matthew Masoli, Mark Weatherall, Carl Burgess, Richard Beasley. Lancet 2003.
  2. Asthma exacerbations and inhaled corticosteroids. Masoli M, Beasley R. Letter - Lancet 2004 Apr 10;363(9416):1236
  3. Dose-response relation of budesonide in adolescents and adults with asthma: meta-analysis. Correspondence: M. Masoli, M. Weatherall, S. Holt, and R. Beasley. Eur. Respir. J., Sep 2004; 24: 513 - 514.

A collaboration between the Plymouth University Peninsula Schools of Medicine and Dentisty and the Plymouth University School of Psychology